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ISLAMIC MEDICAL EDUCATION RESOURCES-03

0103- ENVIRONMENTAL and NUTRITIONAL CORRELATES OF THYROID DISEASES: A META-ANALYSIS

Abstract prepared but not submitted at the Conference on Update of Thyroid Disease Organized by the Kuwait Society for Endocrinology 13-15 March 2001 by Prof Omar Hasan Kasule MB ChB MUK), MPH, DrPH (Harvard), Faculty of Medicine, UIA, PO Box 141 Kuantan Malaysia EM omarkasule@yahoo.com

ABSTRACT

The paper presents a meta analysis of epidemiological studies carried out in 10 south-east Asian countries in the period 1980-2000 on the environmental and nutritional correlates of thyroid disease. Three types of studies are included in the meta analysis: incidence, etiological and intervention studies. Incidence studies cover the wide spectrum of thyroid disease ranging from hypothyroidism through hyperthyroidism and thyroid carcinoma. These studies have shown wide variation in incidence of thyroid disease in various environments the contrast being sharpest between highland and low-lying plains. The countries have varying topography, culture, and nutritional habits. Etiological studies have shown the close relation of thyroid disease with nutrition and type of soil. Dietary iodine seems to be the main dietary factor. Iodine deficiency is exacerbated by pregnancy. Goitrogens cause thyroid disease even in areas where there is adequate iodine intake. Intervention studies have been undertaken by the World Health Organization and governments in the region. These consist of dietary iodine supplementation mostly in the form of iodized salt.

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ŠOmar Hasan Kasule Sr, March 2001